Arsenic trioxide encapsulated liposomes prepared via copper acetate gradient loading method and its antitumor efficiency
نویسندگان
چکیده
منابع مشابه
Antitumor activity of arsenic trioxide on retinoblastoma: cell differentiation and apoptosis depending on arsenic trioxide concentration.
PURPOSE Arsenic trioxide (ATO) targets multiple pathways in malignant cells, resulting in the promotion of differentiation or in the induction of apoptosis. The antitumor activity of ATO on retinoblastoma was investigated. METHODS Human retinoblastoma cells were incubated with various ATO concentrations. The antiproliferative effect of ATO was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-dip...
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Arsenic trioxide, As(2)O(3) (ATO), has been established to be an effective agent for treating acute promyelocytic leukemia, but its effect on solid tumors has not been fully explored. In the present study in a murine xenograft system, we found that ATO significantly inhibited tumor growth of the inoculated human hepatocellular carcinoma cell line HuH7 when administered either intravenously or i...
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At an acute ingestion of arsenic trioxide, nausea, vomiting, diarrhea, and abdominal pain are early symptoms occurring within 30 min to several hours. Primary target organ is the gastrointestinal tract (GIТ), where hemorrhagic gastroenteritis can occur in serious cases. Among cardiovascular symptoms are tachycardia, ventricular fibrillation, and heart failure described. Neurological symptoms ca...
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The relation between exposure to As2O3 fumes and dust, and the urinary excretion of inorganic arsenic metabolites (monomethylarsonic acid, dimethylarsinic acid, unchanged inorganic arsenic) has been studied in 18 workers from a sulphuric acid producing plant. The concentration of arsenic in the breathing zone of each worker was measured during five consecutive days and urine samples were obtain...
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In this paper, the global optimization of a nonconvex objective function under linear and nonlinear differentiable constraints is studied, a reduced gradient and GRG descent methods with random perturbation is proposed and it is desired to establish the global convergence of the algorithm. Some numerical examples are also given by the problems of statistical, octagon, mixture, alkylation and po...
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ژورنال
عنوان ژورنال: Asian Journal of Pharmaceutical Sciences
سال: 2020
ISSN: 1818-0876
DOI: 10.1016/j.ajps.2018.12.002